Diabetes Increases Severe COVID-19 Outcomes Primarily in Younger Adults
| Autor: | Etienne Larger, Emmanuel Cosson, Thomas Moreau, Agnès Hartemann, Christiane Ajzenberg, Sopio Tatulashvili, Etienne Dancoisne, Louis Potier, Muriel Bourgeon, Jean-François Gautier, Sébastien Czernichow, Christel Daniel, Marie-Laure Raffin-Sanson, Ronan Roussel, Philippe Chanson, Bruno Fève, Kankoe Sallah, Marc Diedisheim |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry 030209 endocrinology & metabolism Biochemistry 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Severity of illness medicine 030212 general & internal medicine Young adult Risk factor business.industry Biochemistry (medical) Hazard ratio Confounding Retrospective cohort study medicine.disease 3. Good health business Cohort study |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 106:e3364-e3368 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/clinem/dgab393 |
| Popis: | Context Diabetes is reported as a risk factor for severe coronavirus disease 2019 (COVID-19), but whether this risk is similar in all categories of age remains unclear. Objective To investigate the risk of severe COVID-19 outcomes in hospitalized patients with and without diabetes according to age categories. Design Setting and Participants We conducted a retrospective observational cohort study of 6314 consecutive patients hospitalized for COVID-19 between February and 30 June 2020 in the Paris metropolitan area, France; follow-up was recorded until 30 September 2020. Main Outcome Measure(s) The main outcome was a composite outcome of mortality and orotracheal intubation in subjects with diabetes compared with subjects without diabetes, after adjustment for confounding variables and according to age categories. Results Diabetes was recorded in 39% of subjects. Main outcome was higher in patients with diabetes, independently of confounding variables (hazard ratio [HR] 1.13 [1.03-1.24]) and increased with age in individuals without diabetes, from 23% for those 80 years but reached a plateau after 70 years in those with diabetes. In direct comparison between patients with and without diabetes, diabetes-associated risk was inversely proportional to age, highest in Conclusions Diabetes should be considered as an independent risk factor for the severity of COVID-19 in young adults more so than in older adults, especially for individuals younger than 70 years. |
| Databáze: | OpenAIRE |
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