Tumorförmige bilaterale Amyloidose der Mamma assoziiert mit einem invasiven lobulären Karzinom und Sjögren-Syndrom. Kasuistik und Literaturübersicht

Autor:	R. Würstlein, F. Christ, C. Röcken, R. Bässler
Rok vydání:	2000
Předmět:	Systemic disease Pathology medicine.medical_specialty Amyloid business.industry Amyloidosis Lobular carcinoma Obstetrics and Gynecology medicine.disease Breast cancer Dysplasia Maternity and Midwifery medicine Carcinoma skin and connective tissue diseases business Multiple myeloma
Zdroj:	Geburtshilfe und Frauenheilkunde. 60:645-650
ISSN:	1438-8804 0016-5751
DOI:	10.1055/s-2000-9546
Popis:	A 60-year-old woman with metastatic lobular carcinoma of the left breast and Sjogren's syndrome developed a tumor of the right breast. Histology showed an amyloid tumor. Further studies showed tumor-like amyloidosis of the left breast in apposition to the carcinoma. Immunoelectrophoresis showed IgG gammopathy. There was no Bence-Jones protein in the urine. The presence of amyloid was confirmed with congo red staining and electron microscopy. Systemic amyloidosis, which often arises from monoclonal B-cell dysplasia (e.g., multiple myeloma) or rheumatoid arthritis, can cause diffuse, focal, or tumor-like deposits in the breast. Amyloid tumors, whose etiology is unclear, are rare in the breast and usually mistaken for carcinomas. We found no association between Sjogren's syndrome and amyloidosis or between breast cancer and amyloid tumors. A localized amyloid tumor does not need to be excised and should be distinguished from systemic amyloidosis, which requires treatment.
Databáze:	OpenAIRE
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