Biomarkers of oxidative stress in chronic respiratory diseases
| Autor: | Andrea Pasini, Angelo Corsico, Paolo Degan, Liliya Chamitava, Roberto de Marco, M. Elisabetta Zanolin, Anna Fratta-Pasini, Roberto Bono, Pietro Pirina, Morena Nicolis, Mario Olivieri |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Chronic bronchitis business.industry Urinary system medicine.disease_cause Logistic regression medicine.disease Gastroenterology respiratory tract diseases Urine biomarkers Internal medicine Immunology Exhaled nitric oxide medicine Respiratory system business Oxidative stress Asthma |
| Zdroj: | 6.1 Epidemiology. |
| DOI: | 10.1183/13993003.congress-2015.pa1108 |
| Popis: | Elevated levels of oxidative stress (OxS) may be associated with respiratory diseases. We tested the distribution of biomarkers of OxS in subjects with current, past asthma and chronic bronchitis (CB) in respect to subjects free of respiratory diseases. The data were collected in the Genes Environment Interaction in Respiratory Diseases, multicase-control survey. Urine biomarkers 8-oxo-7,8-dihydro-29-deoxyguanosine (8-oxodG) and 8-isoprostane, as well as Fraction of exhaled Nitric Oxide (FeNO)were determined over the cases of current asthma (n=374), past asthma (n=177), CB (n=188) and the controls (n=476). The association of respiratory diseases with OxS biomarkers was investigated with logistic regression analysis adjusting for sex, age and centre. As compared with controls, subjects with current asthma had significantly higher levels of FeNO, patients with past asthma and CB had increased level of urinary 8-isoprostane. These results were confirmed by the logistic regression with significantly higher level of FeNO in patients with current asthma (p Increased levels of FeNO were found in asthma patients and of 8-isoprostane in subjects with past asthma and in those with CB. |
| Databáze: | OpenAIRE |
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