P–317 Uterine cavity in patients with repeated implantation failure (RIF) and before the first IVFprogram
| Autor: | A. N. Rybina, R Valiev, S Karibayeva, Y Askar, V. N. Lokshin |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Human Reproduction. 36 |
| ISSN: | 1460-2350 0268-1161 |
| Popis: | Study question What is the frequency of uterine pathology and histological analysis of chronic endometritis in the RIF group and in patients before the first IVF program? Summary answer We report a lower incidence of chronic endometritis in the group of patients just preparing for the first IVF program and higher effectiveness What is known already Chronic endometritis (CE) is one of the reasons for implantation failures in IVF cycles. The presence of chronic inflammation in the endometrium changes its susceptibility, resulting in failed implantations and loss of pregnancy. CE diagnostics is rather complicated. Visual examination during hysteroscopy allows one to suspect CE in 20–70%, routine histology - in 10–20%. The new gold standard is immunohistochemistry (IHC). Study design, size, duration A continuous study of 2003 hysteroscopies was carried out, conducted in 1944 patients from May 2018 to January 2020. All patients were divided into 2 groups: 1 - 650 patients preparing for IVF for the first time; 2 - 1294 with repeated implantation failures. Participants/materials, setting, methods All included patients had diagnostic office hysteroscopy (OH) with biopsy and IHC CD 138, CD 20, and CD 8. We compared the frequency of CE detection by visual examination during hysteroscopy, routine histology and IHC of the two groups, as well as the effectiveness of 1 course of antibiotic therapy with CE. Main results and the role of chance In group 1 of women preparing for IVF for the first time, during visual examination by hysteroscopy, CE was detected in 17% (110/650), in group 2 RIF - in 27% (349/1294), p Limitations, reasons for caution The limitations are related to study design. More research is also needed. Wider implications of the findings: The question of overdiagnosis of CE using IHC remains open. Therefore, well-designed prospective studies or RCTs should be conducted to clarify possible correlations between ChE and poor reproductive outcomes and the effectiveness of endometrial interventions and treatments. Trial registration number not avaliable |
| Databáze: | OpenAIRE |
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