Indicators of the cell cycle in the thyroid gland in rats when using infusion of 0.9% NaCl solution on the background of thermal skin burns

Autor:	O.I. Tiron
Rok vydání:	2019
Předmět:	Pulmonary and Respiratory Medicine medicine.medical_specialty Endocrinology medicine.anatomical_structure Chemistry Internal medicine Pediatrics Perinatology and Child Health Thyroid medicine Cell cycle
Zdroj:	Reports of Morphology. 25:52-57
ISSN:	2616-6194 1818-1295
DOI:	10.31393/morphology-journal-2019-25(3)-09
Popis:	Systemic damage of the organs, including the thyroid gland, is one of the key factors in the pathogenesis of burn disease due to thermal skin burns. The aim of this study was to investigate the indices of the cell cycle and DNA fragmentation of thyroid gland cells in rats with the use of infusion of 0.9% NaCl solution against the background of thermal skin burns. Experimental studies were conducted on 60 white male rats weighing 160-180 g, which was subjected to thermal burns of the skin of 2-3 degrees with a total area of 21-23% of the body surface. The first 7 days rats were infused with 0.9% NaCl solution into the inferior vena cava. Animals were removed from the experiment by decapitation (after 1, 3, 7, 14, 21, and 30 days). DNA content in the nuclei of the cells of the thyroid gland of rats was determined by flow cytometry. The statistical processing of the obtained results was carried out in the license package “STATISTICA 6.1” using nonparametric estimation methods. After 1 day after thermal skin damage and using 0.9% NaCl solution, lower (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::537e6dba1954eb92015e5cbbb8fc9879 https://doi.org/10.31393/morphology-journal-2019-25(3)-09 Zobrazit plný text záznamu