Clinicopathological Discrepancies in the Diagnosis of Hepatocellular Carcinoma in Explanted Livers, A Single Center Study on More Than 1500 Transplanted Livers
| Autor: | Hamed Salehi, Bita Geramizadeh, Seyed Ali Malek-Hosseini, Kurosh Kazemi, Saman Nikeghbalian, Alireza Shamsaeefar, Mohammad Baghernezhad |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pathology Hepatology business.industry medicine.medical_treatment 030230 surgery Hepatitis B Liver transplantation medicine.disease Single Center Gastroenterology digestive system diseases Tyrosinemia Transplantation 03 medical and health sciences 0302 clinical medicine Infectious Diseases Hepatocellular carcinoma Internal medicine medicine 030211 gastroenterology & hepatology Tumor location business Pathological |
| Zdroj: | Hepatitis Monthly. 17 |
| ISSN: | 1735-3408 1735-143X |
| DOI: | 10.5812/hepatmon.11836 |
| Popis: | Background: Hepatocellular carcinoma is an unfortunate consequence in cirrhotic patients. Most of the cases are diagnosed by imaging modalities; however, some of them are missed and would be diagnosed only after thorough examination of the explanted liver following transplantation. Objectives: In this study, we aimed to evaluate the frequency of incidental HCCs that are diagnosed after transplantation based on pathological examination of the explanted livers. Methods: We evaluated all the explanted livers during 5 years from 2012 to 2016 with clinical and pathological diagnosis of HCC. In the meantime, all of the clinicopathological findings were investigated such as demographic information, AFP level, tumor size, and tumor location. Conclusions: The frequency of incidental HCC in our center was around 20%, more than 80% of which were less than 2-cm in size (early HCC). Majority of the cases were male patients above 40 years age, with the underlying causes of Hepatitis B, C, and AIH as well as tyrosinemia and PFIC. |
| Databáze: | OpenAIRE |
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