| Autor: |
Ayola A. Adegnika, Nicholas D. Youngblut, Laure Ségurel, Liam Fitzstevens, Ruth E. Ley, Kelsey E Huus, Meral Esen, Bayode Romeo Adegbite, Nina Marchi, Mirabeau Mbong, Peter G. Kremsner, Amanda L. Muehlbauer, Hagay Enav, Tim D. Spector, Jeannot Fréjus Zinsou, Victor T. Schmidt, Taichi A. Suzuki, Thirumalaisamy P. Velavan, Le Huu Song, Ran Blekhman |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.10.12.462973 |
| Popis: |
Some gut microbes have cospeciated with hominids, but whether they further codiversified with human populations is unclear. Here, we identify predominant gut microbial species sharing a parallel evolutionary history with human populations. Patterns of strain transfer between populations are generally consistent with an African origin, and suggest long-term vertical transmission over thousands of generations. We show the same strains also faithfully transmit between mothers and their children. Consistent with the development of intimate symbiosis, species with strongest patterns of codiversification have the smallest genomes. This study reveals long-term fidelity of gut microbiota with human populations through transmission among individuals living in close proximity. Dominance of specific strains in different populations is based in part on vertical transmission and they may provide population-specific health benefits.One-sentence summaryIdentification of gut microbes that codiversified with human populations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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