Expression of Vascular Endothelial Growth Factor in the Rat Brain after Perinatal Hypoxia and Pharmacological Correction
| Autor: | L. I. Khozhai, V. K. Akulova, V. I. Mironova, Natalia Ordyan, A. V. Pritvorova, V. A. Otellin |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Quantitative immunohistochemistry Biochemistry Neuroprotection 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Molecular Biology Neocortex business.industry Perinatal hypoxia Hypoxia (medical) Rat brain Vascular endothelial growth factor 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Late period medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Neurochemical Journal. 13:182-187 |
| ISSN: | 1819-7132 1819-7124 |
| DOI: | 10.1134/s1819712419020077 |
| Popis: | —We studied the role of vascular endothelial growth factor (VEGF) in post-hypoxic damage of the rat brain and in the effect of saliphene, a GABA derivative that is considered as a potential neuroprotector. The method of quantitative immunohistochemistry was used to evaluate the expression of VEGF in the rat brain (neocortex and hippocampus) at the early and late periods after perinatal hypoxia and the subsequent administration of saliphene. Hypoxia resulted in an increase in the expression of vascular endothelial growth factor in the developing rat brain, and injections of saliphene prevented an increase in VEGF expression, leaving this index at the level of the control values. Thus, the changes the expression of vascular endothelial growth factor (VEGF) in the rat brain after perinatal hypoxia may be considered as a marker of the neuroprotective effect of saliphene. |
| Databáze: | OpenAIRE |
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