Feasibility of fabricating personalized 3D-printed bone grafts guided by high-resolution imaging
| Autor: | Rohit Shinde, Jayaram K. Udupa, Chamith S. Rajapakse, Elizabeth A. Kobe, Olivia M. Teter, Daniel Sipzner, Arbab Khalid, Benjamin T. Newman, Abigail L. Hong, Malika Shukurova, Robert J. Pignolo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
3d printed
Computer science Computed tomography 02 engineering and technology computer.software_genre law.invention 03 medical and health sciences 0302 clinical medicine law Voxel Medical imaging medicine Stereolithography Bone geometry Bone growth medicine.diagnostic_test Proximal femur Mesenchymal stem cell 030206 dentistry Microcomputed tomography 021001 nanoscience & nanotechnology 0210 nano-technology computer Bone volume Synthetic bone graft Biomedical engineering |
| Zdroj: | Medical Imaging 2017: Imaging Informatics for Healthcare, Research, and Applications. |
| ISSN: | 0277-786X |
| Popis: | Current methods of bone graft treatment for critical size bone defects can give way to several clinical complications such as limited available bone for autografts, non-matching bone structure, lack of strength which can compromise a patient’s skeletal system, and sterilization processes that can prevent osteogenesis in the case of allografts. We intend to overcome these disadvantages by generating a patient-specific 3D printed bone graft guided by high-resolution medical imaging. Our synthetic model allows us to customize the graft for the patients’ macro- and microstructure and correct any structural deficiencies in the re-meshing process. These 3D-printed models can presumptively serve as the scaffolding for human mesenchymal stem cell (hMSC) engraftment in order to facilitate bone growth. We performed highresolution CT imaging of a cadaveric human proximal femur at 0.030-mm isotropic voxels. We used these images to generate a 3D computer model that mimics bone geometry from micro to macro scale represented by STereoLithography (STL) format. These models were then reformatted to a format that can be interpreted by the 3D printer. To assess how much of the microstructure was replicated, 3D-printed models were re-imaged using micro-CT at 0.025-mm isotropic voxels and compared to original high-resolution CT images used to generate the 3D model in 32 sub-regions. We found a strong correlation between 3D-printed bone volume and volume of bone in the original images used for 3D printing (R2 = 0.97). We expect to further refine our approach with additional testing to create a viable synthetic bone graft with clinical functionality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|