Sorption-desorption test for functional assessment of skin treated with a lipid system that mimics epidermal lamellar bodies

Autor:	Estibalitz Fernández, Alfonso del Pozo, Mercedes Cócera, Olga López, Alfonso de la Maza, Verónica Moner, Gelen Rodríguez
Rok vydání:	2017
Předmět:	Chromatography integumentary system Adsorption desorption Chemistry Lipid composition Sodium chemistry.chemical_element Human skin 02 engineering and technology Dermatology Lamellar granule 021001 nanoscience & nanotechnology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Biophysics Immunology and Allergy 0210 nano-technology Barrier function After treatment
Zdroj:	Contact Dermatitis. 77:25-34
ISSN:	0105-1873
DOI:	10.1111/cod.12771
Popis:	SummaryBackground Many skin diseases are associated with either increases or decreases in lamellar body secretion, or dysfunctional lamellar bodies. Consequently, diseased skin is characterized by reduced barrier function and altered lipid composition and organization. Human skin is commonly evaluated in vivo with non-invasive biophysical techniques. The dynamic functions of the skin are evaluated with repeat measurements such as the sorption–desorption test (SDT). Objectives The aim of this study was to evaluate in vivo skin hydration–dehydration kinetics after treatment with a lipid system that mimics the morphology, structure and composition of lamellar bodies in both healthy and irritated human skin. Methods A patch with an aqueous solution of 2% sodium lauryl sulfate (SLS) was used to irritate the skin of the volunteers. The SDT was performed with the CM 820 corneometer. Results After treatment with this system, both healthy and SLS-irritated skin increased their ability to retain water and to release water slowly during the desorption phase. Conclusions Treatment with this system seems to reinforce the barrier function in both healthy and SLS-irritated human skin. Therefore, the present study provides evidence that this system could be of interest for developing future treatments for protecting and repairing the skin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::536fc727519bcb12808c819f42ad2196 https://doi.org/10.1111/cod.12771 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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