Uraemic toxin reduction: A newly found effect of hydrolysable-type tannin-containing crude drug and gallotannin
| Autor: | Itsuo Nishioka, Gen-ichiro Nonaka, Hikokichi Oura, Takako Yokozawa, Takashi Tanaka, Koji Fujioka |
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| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Paeonia lactiflora medicine.medical_specialty Creatinine biology Toxin Biological activity Crude drug biology.organism_classification medicine.disease_cause chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine Methylguanidine Tannin Gallotannin |
| Zdroj: | Phytotherapy Research. 9:327-330 |
| ISSN: | 1099-1573 0951-418X |
| DOI: | 10.1002/ptr.2650090504 |
| Popis: | The levels of urea nitrogen, creatinine, methylguanidine and guanidinosuccinic acid, which accumulate in blood in parallel with the progress of renal failure after adenine administration, were decreased significantly in rats given Galla Rhois, Moutan Cortex or Paeoniae Radix extract. Administration of Galla Rhois extract was found to be more effective than the other two crude drugs in decreasing the uraemic toxin parameters. A uraemic toxin-decreasing effect similar to that of crude drug was also obtained using 1,3,6-tri-O-galloyl-β-D-glucopyranose and 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose. |
| Databáze: | OpenAIRE |
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