Tumor‐associated macrophages as treatment targets in glioma
Autor: | Chunna Yu, Can Wang, Yichen Peng, Feng Chen, Wenbin Li, Xiu Liu, Shenglan Li |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Polymers and Plastics business.industry medicine.medical_treatment Central nervous system Immunotherapy medicine.disease World health 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Treatment targets Tumor progression 030220 oncology & carcinogenesis Glioma medicine Cancer research business General Environmental Science |
Zdroj: | Brain Science Advances. 6:306-323 |
ISSN: | 2096-5958 |
Popis: | Gliomas, the most common primary tumors in the central nervous system (CNS), can be categorized into 4 grades according to the World Health Organization. The most malignant glioma type is grade Ⅳ, also named glioblastoma multiforme (GBM). However, the standard treatment of concurrent temozolomide (TMZ) chemotherapy and radiotherapy after maximum resection does not improve overall survival in patients with GBM. Targeting components of the CNS microenvironment represents a new strategy for improving the efficacy of glioma treatment. Most recent studies focused on T cells. However, there is a growing body of evidence that tumor‐associated macrophages (TAMs) play an important role in tumor progression and can be regulated by a wide array of cytokines or chemokines. New TAM‐associated immunotherapies may improve clinical outcomes by blocking tumor progression and prolonging survival. However, understanding the exact roles and possible mechanisms of TAMs in the tumor environment is necessary for developing this promising therapeutic target and identifying potential diagnostic markers for improved prognosis. This review summarizes the possible interactions between TAMs and glioma progression and discusses the potential therapeutic directions for TAM‐associated immunotherapies. |
Databáze: | OpenAIRE |
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