Autor: |
Sven Frokjaer, Steffen W Jorgensen, Helle Brøndsted, Lars Hovgaard, Peter Eigtved |
Rok vydání: |
1998 |
Předmět: |
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Zdroj: |
International Journal of Pharmaceutics. 161:109-114 |
ISSN: |
0378-5173 |
DOI: |
10.1016/s0378-5173(97)00335-9 |
Popis: |
Phenylalanine ammonia-lyase (PAL) which is an enzyme capable of converting l -phenylalanine to trans -cinnamic acid has been shown to be able to minimize the amount of l -phenylalanine transported across Caco-2 monolayers when administered apically. The impact of this is that a formulation of PAL, able to lower the transport of l -phenylalanine across epithelia, potentially could be applied in the oral treatment of phenylketonuria. Confluent monolayers of Caco-2 cells were shown to simplify the studying of the simultaneous events of conversion and transport across an epithelial barrier. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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