Abstract P342: Histopathological Correlates of MRI-Visible Perivascular Spaces in Cerebral Amyloid Angiopathy
| Autor: | Leon P Munting, Whitney Freeze, Steven M. Greenberg, Ashley A Scherlek, Valentina Perosa, Anand Viswanathan, Susanne J. van Veluw |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Advanced and Specialized Nursing
Pathology medicine.medical_specialty medicine.diagnostic_test Amyloid business.industry Magnetic resonance imaging medicine.disease medicine.anatomical_structure mental disorders Centrum semiovale cardiovascular system medicine Neurology (clinical) Cerebral amyloid angiopathy Perivascular space Cardiology and Cardiovascular Medicine business |
| Zdroj: | Stroke. 52 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/str.52.suppl_1.p342 |
| Popis: | Perivascular spaces (PVS) are fluid-filled spaces surrounding cerebral blood vessels. MRI-visible, supposedly enlarged, PVS in the centrum semiovale (CSO) have been associated with cerebral amyloid angiopathy (CAA). PVS enlargement may be due to perivascular clearance impairments, potentially caused by increased amyloid-β (Aβ) accumulation in the walls of vessels in the overlying cortex. We test this hypothesis, using MRI-guided histopathological examination of PVS in CAA autopsy cases. The cohort included 19 CAA (74.1±8.2y, 7F) and 5 non-CAA control cases (88.0±4.9y, 3F). Formalin-fixed hemispheres were scanned on a 3T MRI scanner, including a 500μm T2-weighted sequence. PVS enlargement was assessed in the CSO on in vivo and ex vivo MRI. In addition, local score of PVS enlargement was assessed in four pre-defined juxtacortical areas (Fig.A), using a semiquantitative score and on the corresponding histological sections (Fig.B). Severity of leptomeningeal and cortical CAA were assessed on adjacent Aβ-stained sections, using a semiquantitative scale.PVS enlargement was more severe in CAA cases compared to controls, both on in vivo and ex vivo MRI (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|