ChemInform Abstract: Synthesis and Structure-Activity Relationship of Substituted 1,2,3,4-Tetrahydroisoquinolines as N-Type Calcium Channel Blockers

Autor:	Katalin Tarczy-Hornoch, Balazs G. Szoke, Schelkun Robert Michael, Po-Wai Yuen
Rok vydání:	2010
Předmět:	Chemistry Stereochemistry Voltage activated calcium channel Functional activity Structure–activity relationship General Medicine N-type calcium channel
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
Popis:	Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N-type VACC's have been identified. Their synthesis and preliminary pharmacology are discussed herein.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::533538538608e1f8d45b9ff865179501 https://doi.org/10.1002/chin.199902147 Zobrazit plný text záznamu Plný text