Calciumantagonisten bei chronischer Niereninsuffizienz: Unerwünschte Effekte auf die glomeruläre Hämodynamik?
| Autor: | Johannes F.E. Mann, Th. Helder, Eberhard Ritz, E.-W. Rauterberg, O. Mickisch, F. Bergen, M. Schmid |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Afferent arterioles Proteinuria medicine.diagnostic_test biology business.industry Antagonist chemistry.chemical_element Glomerulonephritis General Medicine Calcium urologic and male genital diseases medicine.disease Endocrinology medicine.anatomical_structure chemistry Enzyme inhibitor Internal medicine Biopsy medicine Albuminuria biology.protein medicine.symptom business |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 113:1546-1548 |
| ISSN: | 1439-4413 0012-0472 |
| Popis: | Seven patients with glomerular proteinuria and hypertension (six with biopsy confirmation of glomerulonephritis, one with proteinuria after unilateral nephrectomy) were randomly given, for 14 days each, a calcium antagonist and then a conversion enzyme inhibitor, or vice versa, following a 14-day pause of all medication. Fractional albuminuria rose significantly during administration of calcium antagonists (P less than 0.05), while it decreased significantly during administration of converting enzyme inhibitor (P less than 0.05). The explanation for this finding may be that calcium antagonists raise glomerular capillary pressure by dilating the afferent arterioles, while converting enzyme inhibitors predominantly cause dilatation of the efferent arterioles. |
| Databáze: | OpenAIRE |
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