Synthesis and pharmacological evaluation of novel 1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one derivatives as potential antimicrobial agents

Autor:	Hasmukh Joshi, Vimal Patel, Pralav Bhatt, Nilay Bhatt
Rok vydání:	2013
Předmět:	Antifungal chemistry.chemical_classification Chemistry medicine.drug_class Aryl Organic Chemistry Pharmacology toxicology Alkylation Antimicrobial Combinatorial chemistry chemistry.chemical_compound medicine Organic chemistry General Pharmacology Toxicology and Pharmaceutics Alkyl
Zdroj:	Medicinal Chemistry Research. 23:2133-2139
ISSN:	1554-8120 1054-2523
Popis:	Novel compounds of biological interest were synthesized by in situ reduction of Schiff’s base of 5,6-dimethoxy indanone and 1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one in the presence of Ti(OiPr)4 and NaBH3CN. Further alkylation using different alkyl/aryl halides in the presence of NaH in DMF gave a series of novel compounds. A formation of newly synthesized compounds was confirmed on the basis of their spectral and elemental analysis. Further these compounds were screened for their antimicrobial activity and found to have promising antibacterial and antifungal activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::53276f24332af77ede5ea7433ae89b08 https://doi.org/10.1007/s00044-013-0799-6 Zobrazit plný text záznamu Full text from SpringerLink