Winchinines A and B, two unusual monoterpene indole alkaloids with a third nitrogen atom from Winchia calophylla
| Autor: | Lei Wang, Xiao-Qi Zhang, Ren-Wang Jiang, Wen-Cai Ye, Wei Zhang, Yu-Ting Li, Xian-da Gao, Dong-Mei Zhang, Xiao-Jun Huang |
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| Rok vydání: | 2016 |
| Předmět: |
Indole test
Circular dichroism 010405 organic chemistry Chemistry Stereochemistry General Chemical Engineering Monoterpene Alkaloid General Chemistry Nuclear magnetic resonance spectroscopy 010402 general chemistry Ring (chemistry) 01 natural sciences 0104 chemical sciences Nitrogen atom Single crystal |
| Zdroj: | RSC Advances. 6:59657-59660 |
| ISSN: | 2046-2069 |
| Popis: | Two novel monoterpenoid indole alkaloids (MIAs) with a third nitrogen atom, winchinines A (1) and B (2), along with three known ones (3–5) were isolated from the twigs and leaves of Winchia calophylla. Compound 1 is the first natural MIA possessing a 6/5/6/5/6/5 hexacyclic ring system with an oxazolidinone unit. Compound 2 is an unprecedented cyano-substituted aspidosperma-type alkaloid. Their structures with absolute configurations were elucidated by means of NMR spectroscopy, single crystal X-ray diffraction, and electronic circular dichroism data analyses. |
| Databáze: | OpenAIRE |
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