INHIBITION OF STRESS-INDUCED ACTH SECRETION BY NOREPINEPHRINE IN THE DOG: MECHANISM AND SITE OF ACTION11Supported by USPHS Grant AMO6704 and Kroc Foundation
| Autor: | William F. Ganong, Roy Shackelford, Ian A. Reid, Norman Kramer, A. T. Boryczka |
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| Rok vydání: | 1976 |
| Předmět: |
endocrine system
medicine.medical_specialty business.industry Adrenocorticotropic hormone Venous blood Methamphetamine Norepinephrine (medication) Endocrinology Dopamine Internal medicine medicine ACTH receptor Secretion Amphetamine business hormones hormone substitutes and hormone antagonists medicine.drug |
| DOI: | 10.1016/b978-0-08-020588-5.50024-2 |
| Popis: | Publisher Summary This chapter discusses the mechanism and site of action for the inhibition of stress-induced adrenocorticotropic hormone (ACTH) secretion by norepinephrine in the dog. In the dog, centrally active sympathomimetic drugs inhibit stress-induced ACTH secretion. The drugs found to have this action include α-ethyltryptamine, α -methyltryptamine, amphetamine, methamphetamine, 2-aminoheptane, and Clopane. L-dopa also inhibits ACTH secretion. In experiments, adrenal venous corticoid output was used as the index of ACTH secretion. Exogenous ACTH was given at the end of each experiment to demonstrate that the adrenal was normally responsive. The stress in all cases was a surgical laparotomy, with adrenal venous blood being collected after the start of the operation. Catecholamines fail to penetrate the brain in appreciable amounts when administered systemically. Norepinephrine and dopamine inhibit ACTH secretion when given directly into the third ventricle, but fail to inhibit ACTH secretion when given systemically. |
| Databáze: | OpenAIRE |
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