ABCL-328: Lymphoma Associated with HIV Infection: Prevalence, Clinical Characteristics, Treatment, and Outcomes

Autor: Marcelo Lavarda, Maria Laura Rizzi, Rodrigo Meneces Bustillo, Gustavo Jarchum, Maria Alvarez Bollea, Evelyn Colombo, Sol Jarchum
Rok vydání: 2020
Předmět:
Zdroj: Clinical Lymphoma Myeloma and Leukemia. 20:S273-S274
ISSN: 2152-2650
Popis: Context: In Argentina, it is estimated that there are approximately 139,000 people living with HIV infection (PLWHIV), of whom 17% are unaware of their infection. HIV infection generates a greater risk of developing neoplastic pathologies, with NHL as one of the most frequent. Objective: Determine the prevalence of lymphoma in PLWHIV, their clinical characteristics, and their outcomes. Design: Observational, retrospective, longitudinal trial with PLWHIV and lymphoma registered from 2015 to 2019 at our hospital were reviewed. Mean follow-up was 24.5 months. Setting: Hospital care, high-complexity center. Patients or other participants: Two hundred seven patients diagnosed with HIV. The median age was 36.5 years. Interventions: Follow-up after diagnosis. Main outcome measures: Comparison between means by an ANOVA test and then a Chi-square test to assess the association between groups. Results: Of 207 patients diagnosed with HIV, 10% (n=20) had lymphoma. Forty percent of them were undergoing treatment before diagnosis, and the median time to lymphoma onset was 6 years. Sixty percent had the diagnosis of lymphoma and HIV simultaneously. The prevalence of NHL was 85%. DLBCL and BL were the most frequent (41% each), followed by T-cell lymphoma 12% and CNS primary lymphoma 6%. The remaining 15% were HL (nodular sclerosis 33% and mixed cellularity 66%). CNS involvement was 20% at the diagnosis and 10% at bone marrow. Stage III/IV was present in 75% and IPI (intermediate/high risk) in 50%. No significant difference was observed when CD4 count and viral load values were analyzed with the stage at diagnosis (p=0.77 and p=0.94, respectively). The CR rate was 87%. After analyzing NHL and HL, CR after induction were 65% and 100%, respectively. There were two chemotherapy-related deaths associated with sepsis. Only 2 of 20 patients required second-line therapy and HSCT. Conclusions: In our HIV population, the prevalence of lymphoma was 10%, with good results after chemotherapy. There was high incidence of simultaneous diagnosis. CD4+ count and viral load were not statistically related to clinical stage, type of lymphoma, or outcomes, but advanced-stage, higher IPI, and CNS involvement at presentation prevailed. Higher incidence of mortality due to neutropenic sepsis occurred in our patients. CD4+
Databáze: OpenAIRE
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