Alternative therapies for denture stomatitis treatment: in vivo experimental model in rats
| Autor: | Gabriela de Fátima Santana-Melo, Cybelle Mori Hiraoka, Cristiane Yumi Koga-Ito, Gabriela de Morais Gouvêa Lima, Fernanda Lourenção Brighenti, Marina Bacelar Silva, Patricia Carla Lopes, Daniel Freitas Alves Pereira, Guilherme Rodrigues Teodoro |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Sodium bicarbonate biology business.industry Experimental model Pharmacology medicine.disease biology.organism_classification Corpus albicans chemistry.chemical_compound Nystatin chemistry In vivo Male rats Medicine business Candida albicans General Dentistry Stomatitis medicine.drug |
| Zdroj: | Brazilian Dental Science. 20:70-79 |
| ISSN: | 2178-6011 |
| DOI: | 10.14295/bds.2017.v20i1.1368 |
| Popis: | Background: Denture stomatitis (DS) is a multifactorial condition that commonly affects denture users and is mainly caused by Candida albicans . Due to the toxic effects of antifungal therapy, new therapies for DS are claimed. Objective: The aim of the study was to evaluate the efficacy of aqueous extract of Buchenavia tomentosa and sodium bicarbonate against C. albicans in a model of DS in rats. Material and Methods: An acrylic resin device simulating a denture base was fixed covering the palate of forty-eight male rats followed by candidiasis induction. Rats were divided into 4 groups (n=12): Control, sodium bicarbonate, B. tomentosa and nystatin (positive control). Each group was subdivided according to the period of treatment; 24 hours (n=6) and 48 hours (n=6). Animals were sacrificed and had their devices removed for C. albicans counts and SEM analysis. The palate mucosa was removed and processed for histopathologic analysis. Results: After 24 hours of treatment, both B. tomentosa and nystatin groups reduced significantly C. albicans counts when compared to control (nystatin x control, p |
| Databáze: | OpenAIRE |
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