Enantioselective synthesis of sulfoxides catalysed by an oxidase–peroxidase bienzymatic system

Autor:	Eryka Guibé-Jampel, Krzysztof Okrasa, Aude Falcimaigne, Michel Therisod
Rok vydání:	2002
Předmět:	chemistry.chemical_classification Oxidase test biology Chemistry Organic Chemistry Enantioselective synthesis Catalysis Amino acid Inorganic Chemistry chemistry.chemical_compound biology.protein Organic chemistry Physical and Theoretical Chemistry Enantiomeric excess Hydrogen peroxide Peroxidase
Zdroj:	Tetrahedron: Asymmetry. 13:519-522
ISSN:	0957-4166
DOI:	10.1016/s0957-4166(02)00142-8
Popis:	We have devised a new bienzymatic oxidase–peroxidase system in which hydrogen peroxide is produced from air by a d -amino acid oxidase. The generated hydrogen peroxide is instantly used for asymmetric oxygenation of sulphides by a peroxidase. In the absence of peroxidase no spontaneous oxidation is observed, indicating that hydrogen peroxide production by the d -amino acid oxidase is fully controlled. Arylmethyl sulfoxides can be synthesised on a preparative scale with high yields and good enantiomeric excess.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5305339f5d0a53e3bedf8774cf1fcdc8 https://doi.org/10.1016/s0957-4166(02)00142-8 Zobrazit plný text záznamu Full Text from ScienceDirect