Synthesis of the Tetraketide Lactones from the Pikromycin Biosynthetic Pathway

Autor:	Han-Young Kang, David H. Sherman, Hong Se Oh, Ki Hyun Nah, Ji Suk Yun
Rok vydání:	2007
Předmět:	biology Stereochemistry Organic Chemistry Enantioselective synthesis Combinatorial chemistry Polyketide chemistry.chemical_compound Aldol reaction chemistry Biosynthesis Polyketide synthase biology.protein Physical and Theoretical Chemistry Reformatsky reaction Pikromycin
Zdroj:	European Journal of Organic Chemistry. 2007:3369-3379
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.200700254
Popis:	Synthesis of tetraketide lactones 2 and 3, which are likely to be produced by a model pikromycin polyketide synthase (PKS), has been investigated. The tetraketide lactones with six-membered rings, 2a and 2b, were synthesized successfully by the asymmetric aldol reaction, allylation, and the Reformatsky reaction. The attempted synthesis of tetraketide lactones with eight-membered rings, 3a and 3b, led to the formation of the compounds 2a and 2b. The synthesis of an
Databáze:	OpenAIRE
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