Processes of Encapsulation and Crystallization of Prednisolon in PAAm-b-PEO-b-PAAm Micellar Solutions

Autor:	Dmytro Klymchuk, Vasil Gorchev, Tatyana Zheltonozhskaya, Sofia Partsevskaya
Rok vydání:	2014
Předmět:	Materials science Ethylene oxide Polyacrylamide General Chemistry Condensed Matter Physics Micelle law.invention chemistry.chemical_compound chemistry law Polymer chemistry Micellar solutions Copolymer General Materials Science Crystallization
Zdroj:	Molecular Crystals and Liquid Crystals. 590:140-148
ISSN:	1563-5287 1542-1406
DOI:	10.1080/15421406.2013.874155
Popis:	Micellar solutions of PAAm-b-PEO-b-PAAm triblock copolymer (TBC) based on chemically complementary poly(ethylene oxide) and polyacrylamide (Mn= 6 and 116 kDa) were applied to study the encapsulation of poorly soluble crystallizing drug prednisolon (PS) in a region of ϕ= 0.065 ÷ 0.39 molPS/base-molTBC. The equilibrium mechanism of the encapsulation and the effect of specific aggregation of small and large PS-loaded micelles by their “coronas” that promoted the drug crystallization were established. The fractal character of large drug-loaded micelles and unusual morphology of PS crystals allowed assuming the presence of TBC micelles inside crystalline space.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::53032f15f3b740fd51e47b236ce4a27b https://doi.org/10.1080/15421406.2013.874155 Zobrazit plný text záznamu