Differential Neural Correlates of Set-Shifting in the Bingeing-Purging and Restrictive Subtypes of Anorexia Nervosa: An fMRI Study
| Autor: | Wouter De Baene, Kees van Heeringen, Nikita Vancayseele, Myriam Vervaet, Sara Van Autreve, Chris Baeken |
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| Rok vydání: | 2016 |
| Předmět: |
Neural correlates of consciousness
medicine.diagnostic_test Bulimia nervosa Cognitive flexibility Precuneus medicine.disease behavioral disciplines and activities 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health Clinical Psychology Eating disorders 0302 clinical medicine medicine.anatomical_structure Anorexia nervosa (differential diagnoses) medicine Functional magnetic resonance imaging Psychology Insula 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | European Eating Disorders Review. 24:277-285 |
| ISSN: | 1072-4133 |
| Popis: | In this study, possible differences in the neural correlates of set-shifting abilities between the restrictive (AN-R) and bingeing/purging (AN-BP) subtypes of anorexia nervosa have been explored. Three groups of participants performed a set-shifting task during functional magnetic resonance imaging: patients with AN-R (N = 16), AN-BP (N = 13) and healthy control participants (N = 15). As in a typical set-shifting experiment, participants had to switch between two easy tasks (i.e. ‘Is the presented number odd/even’ or ‘Is the presented number smaller/larger than 5’). The trials in which the task was repeated (repeat trials) were compared with trials in which the task was switched (switch trials). With regards to the level of task performance, no significant group differences could be established. However, when comparing switch specific brain activity across study groups, a stronger activation was found in the insula and the precuneus in AN-R when compared to AN-BP and HC. These results suggest that the both subtypes of AN might have different neurobiological correlates, and thus, might benefit from different treatment approaches. |
| Databáze: | OpenAIRE |
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