Effect of aqueous antler extract on scopolamine-induced memory impairment in mice and antioxidant activities
| Autor: | Eun-Kyung Mo, Mi-Ra Lee, Dong-Liang Zhang, Lei Liu, Sung-Young Ly, Li-Juan Gu, C.Y. Wang, Chun-Yan Wang, Beom-Sik Yun, Chang-Keun Sung, Zhen Wang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
chemistry.chemical_classification
Antioxidant biology medicine.medical_treatment Glutathione peroxidase Morris water navigation task Pharmacology Malondialdehyde Applied Microbiology and Biotechnology Acetylcholinesterase Choline acetyltransferase Superoxide dismutase chemistry.chemical_compound chemistry Biochemistry Tacrine biology.protein medicine Food Science Biotechnology medicine.drug |
| Zdroj: | Food Science and Biotechnology. 19:655-661 |
| ISSN: | 2092-6456 1226-7708 |
| Popis: | This study was performed to estimate ameliorating effect of aqueous antler extract (AAE) on memory impairments induced by scopolamine (SCOP, 2 mg/kg, i.p.). Tacrine (THA, 10 mg/kg, p.o.) was used as a positive control. The passive avoidance test and Y-maze test results showed that a single AAE (200 mg/kg, p.o.) administration significantly restored memory impairment. Moreover, AAE or THA treatment significantly reduced the escape latency prolonged by SCOP during trial sessions in the Morris water maze test. In vivo study, AAE significantly inhibited acetylcholinesterase (AChE) activity (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink