A potent small-molecule inducer of chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells

Autor:	Jeong Ae Lee, Dong-Sup Lee, Jonghoon Kim, Keunhee Oh, Seung Bum Park, Soon Keun Kwon, Tae Jun Cho, Jaejin Cho
Rok vydání:	2012
Předmět:	medicine.anatomical_structure Directed differentiation Chemistry Mesenchymal stem cell medicine food and beverages Human bone Inducer General Chemistry Chondrogenesis Small molecule Chondrocyte Cell biology
Zdroj:	Chemical Science. 3:3071
ISSN:	2041-6539 2041-6520
DOI:	10.1039/c2sc20362f
Popis:	We discovered a novel small-molecule modulator 5{i,2} that can specifically induce the chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs). Based on our biochemical and histological studies, 5{i,2} showed more of a directed differentiation of MSCs to chondrocyte balls compared to TGF-β3.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::52f3bdce8ce279373dc107587f61b8c7 https://doi.org/10.1039/c2sc20362f Zobrazit plný text záznamu