Asymmetric ketone reduction using chiral oxazaborolidines derived from aziridine carbinols

Autor:	J. G. H. Willems, Jeannet B. Hammink, F. Jan Dommerholt, Lambertus Thijs, Binne Zwanenburg, Ariëla M. Vaarhorst
Rok vydání:	1995
Předmět:	chemistry.chemical_classification Ketone Organic Chemistry Alcohol Borane Aziridine Biochemistry Catalysis Reduction (complexity) chemistry.chemical_compound chemistry Drug Discovery Organic chemistry Acetophenone
Zdroj:	Tetrahedron Letters. 36:603-606
ISSN:	0040-4039
DOI:	10.1016/0040-4039(94)02313-z
Popis:	Asymmetric borane reduction of acetophenone using 1,3,2-oxazaborolidines derived from aziridine-2-tertiairy alcohols 1 and 2 yielded the corresponding alcohol in high optical yields. The synthesis of the novel chiral catalysts 1 and 2 using D-and L-serine, and D-and L-threonine as starting material is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::52d846d336fad091e6fac588dd909804 https://doi.org/10.1016/0040-4039(94)02313-z Zobrazit plný text záznamu Full Text from ScienceDirect