Anisotropy of crystal structure distortion in organic molecular crystals of drugs induced by hydrostatic compression

Autor:	T. P. Shakhtshneider, H. Ahsbahs, H. Uchtmann, Elena V. Boldyreva, M. A. Vasilchenko
Rok vydání:	1999
Předmět:	Solid-state physics Chemistry Hydrogen bond Hydrostatic pressure Diamond Crystal structure engineering.material Compression (physics) Inorganic Chemistry Crystallography symbols.namesake Materials Chemistry engineering symbols Physical and Theoretical Chemistry van der Waals force Anisotropy
Zdroj:	Journal of Structural Chemistry. 40:892-898
ISSN:	1573-8779 0022-4766
DOI:	10.1007/bf02700697
Popis:	Variation of the unit cell parameters of paracetamol and phenacetin as a function of hydrostatic pressure was studied by X-ray diffractometry in diamond anvils. At elevated pressure (4 GPa), the crystal structures undergo anisotropic distortion. The greatest compression was observed in the directions in which the molecules are linked by van der Waals forces alone. Compressibility of the structures in the direction of hydrogen bonds depends on the presence of other types of interaction and on molecular arrangement in the crystals. In the case of paracetamol, integrated compression of the structure led to its stretching in definite crystallographic directions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::52d737382a14a27d74da9cdcd4fd23d9 https://doi.org/10.1007/bf02700697 Zobrazit plný text záznamu Full text from SpringerLink