| Autor: |
Saggu, Raman, Schumacher, Toni, Gerich, Florian, Rakers, Cordula, Tai, Khalid, Delekate, Andrea, Gabor Petzold |
| Rok vydání: |
2016 |
| Předmět: |
|
| DOI: |
10.6084/m9.figshare.c.3630080_d1.v1 |
| Popis: |
Histological and immunohistochemical changes induced by BCAS. The corpus callosum is delineated by yellow dashed lines in all images. (A) Luxol Fast Blue (LFB) staining of the corpus callosum in sham-treated mice and mice subjected to BCAS revealed fibre disarrangement, vacuoles and focal demyelination following BCAS. (B) Astrocytes, stained by an anti-GFAP antibody, became reactive, as indicated by higher area coverage, larger cell diameters, and longer processes. (C) The number of Iba1-positive microglia increased within the corpus callosum. (D) The signal intensity of axons stained with the pan-axonal marker SMI312 decreased after BCAS, indicative of axonal damage. (E) The number of NeuN-positive neuronal cell bodies was comparable in both groups. Scale bars, 100 Îźm. (PDF 7114 kb) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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