Pd/C-catalyzed alkynylation of β-chloroacroleins

Autor:	Nalivela Kumara Swamy, Khagga Mukkanti, Manojit Pal, J. Moses Babu, G. Dhananjaya, Rabin Bera, P. Rajender Kumar
Rok vydání:	2007
Předmět:	Alkynylation Chemistry Organic Chemistry Drug Discovery Sonogashira coupling Efficient catalyst Biochemistry Medicinal chemistry Palladium catalyst Coupling reaction Catalysis
Zdroj:	Tetrahedron. 63:13018-13023
ISSN:	0040-4020
DOI:	10.1016/j.tet.2007.10.013
Popis:	The first Pd/C-mediated Sonogashira coupling of β-chloroacroleins with terminal alkynes is described here. Pd/C–CuI–PPh3 was found to be an efficient catalyst system for this coupling reaction. Using this economic and general process a variety of 4-alkynyl-2H-chromene-3-carbaldehydes and 5-alkynyl-2,3-dihydro benzo[b]oxepine-4-carbaldehydes were prepared in good yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::52d71b23f19f56af9e84dba940306994 https://doi.org/10.1016/j.tet.2007.10.013 Zobrazit plný text záznamu Full Text from ScienceDirect