The life history of Drosophila sperm involves molecular continuity between male and female reproductive tracts

Autor:	Erin L. McCullough, Emma Whittington, Akanksha Singh, Scott Pitnick, Mariana F. Wolfner, Steve Dorus
Rok vydání:	2022
Předmět:	endocrine system Multidisciplinary urogenital system reproductive and urinary physiology
Zdroj:	Proceedings of the National Academy of Sciences. 119
ISSN:	1091-6490 0027-8424
DOI:	10.1073/pnas.2119899119
Popis:	Significance In species with internal fertilization, sperm spend an important part of their lives within the female. To examine the life history of the sperm during this time, we used semiquantitative proteomics and sex-specific isotopic labeling in fruit flies to determine the extent of molecular continuity between male and female reproductive tracts and provide a global catalog of sperm-associated proteins. Multiple seminal fluid proteins and female proteins associate with sperm immediately after mating. Few seminal fluid proteins remain after long-term sperm storage, whereas female-derived proteins constitute one-fifth of the postmating sperm proteome by then. Our data reveal a molecular “hand-off” from males to females, which we postulate to be an important component of sperm–female interactions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::52c4bfc658ddd899e342736002cc4163 https://doi.org/10.1073/pnas.2119899119 Zobrazit plný text záznamu