P6562The relationship between serum potassium concentrations and electrocardiographic characteristics in 163,547 individuals from primary care
| Autor: | Steen Møller Hansen, Regitze Kuhr Skals, Kristian Kragholm, Adrian Pietersen, Claus Graff, Christian Torp-Pedersen, Anders G. Holst, Jørgen K. Kanters, Christoffer Polcwiartek, Maria Lukács Krogager, J. B. Nielsen, Rikke Nørmark Mortensen, P Soegaard |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | European Heart Journal. 40 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehz746.1152 |
| Popis: | Aims Potassium disturbances are common and associated with increased morbidity and mortality, even in patients without prior cardiovascular disease. We examined six electrocardiographic (ECG) measures and their association to serum potassium levels. Methods and results From the Copenhagen General Practitioners' Laboratory, we identified 163,547 individuals aged ≥16 years with a first available ECG and a concomitant serum potassium measurement during 2001–2011. Restricted cubic splines curves showed a non-linear relationship between potassium and the Fridericia corrected QT (QTcF) interval, T-wave amplitude, morphology combination score (MCS), PR interval, P-wave amplitude and duration. Therefore, potassium was stratified in two intervals K: 2.0–4.1 mmol/L and 4.2–6.0 mmol/L for further analyses. Within the low potassium range, we observed: QTcF was 12.5 ms longer for each mmol/L decrease in potassium (p Restricted cubic splines on adjusted lin Conclusion The association of potassium with six commonly measured ECG parameters was non-linear. Strong associations between ECG abnormalities and potassium were seen among individuals with lower potassium levels (≤4.1 mmol/L). Acknowledgement/Funding None |
| Databáze: | OpenAIRE |
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