Seasonal variations of 25-hydroxyvitamin d in young and old people in Buenos Aires

Autor: M. Glerean, L. Camera, L. Plantalech, M.F. Picasso, Juliana Fassi, Aida Furci
Rok vydání: 2001
Předmět:
Zdroj: Bone. 29:310
ISSN: 8756-3282
Popis: calcidiol that increase serum parathyroid hormone (PTH). It is unknown, however, the level at which serum calcidiol can influence bone mineral density (BMD). This study aims to determine the serum calcidiol levels that influence BMD in PMW. Moreover, we studied the prevalence of hypovitaminosis D in this population based in these calcidiol latter levels. Measurements of calcidiol and PTH in serum and bone densitometry of the spine and hip (Hologic QRD-1000) were carried out in 171 (47–66 years of age) PMW with natural menopause of 7.9 6 2 (mean 6 SD) years and no treatment, who visited an outpatient rheumatology clinic in Madrid between November and June. No correlation between calcidiol and PTH was observed. In the overall group, and in women with calcidiol .15 ng/mL, PTH was inversely related to hip and spine BMD. However, when considering PMW with levels of calcidiol at ,15 ng/mL, a direct relationship between calcidiol and BMD of the hip was observed. By performing multiple stepwise regression analysis, it was observed that calcidiol is the only factor affecting BMD of the hip in the subgroup with serum calcidiol levels ,15 ng/mL; meanwhile, in the PMW subgroup with calcidiol .15 ng/mL, PTH was the main factor influencing hip BMD. With these results, a threshold of deficiency was established at 15 ng/mL calcidiol. The prevalence of this deficiency in PMW was 64%. Concentrations of serum calcidiol of ,15 ng/mL affect BMD, regardless of PTH. Deficiency of vitamin D is a very common finding in PMW attending this outpatient rheumatology clinic. Thus, it is advisable to prescribe vitamin D supplements for this population during the winter months.
Databáze: OpenAIRE
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