Occurrence and distribution of atrial natriuretic peptide-containing cells in the left ventricle of hypertensive rats
| Autor: | Victor Belkin, Jutta Schaper, Wolfgang Schaper, Ella Kaganovsky, Yael Barhum, Gania Kessler-Icekson |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Histology business.industry Captopril Cell Biology Hydralazine Pathology and Forensic Medicine Muscle hypertrophy Endocrinology medicine.anatomical_structure Spontaneously hypertensive rat Nifedipine Atrial natriuretic peptide Ventricle Internal medicine cardiovascular system medicine Cardiology Myocyte business hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | Cell and Tissue Research. 303:57-67 |
| ISSN: | 1432-0878 0302-766X |
| Popis: | In the ventricles of adult mammalian hearts, production of atrial natriuretic peptide (ANP) is negligible, restricted to the impulse-conducting cells, the papillary muscles, and a minority of subendocardial myocytes. ANP expression is reinduced in the ventricles of pressure-overloaded and failing hearts and is frequently used as a marker for myocyte hypertrophy. Using an immunohistochemical approach, we have characterized the size distribution of ANP-containing myocytes in the left ventricle of the spontaneously hypertensive rat (SHR) before and after chronic antihypertensive therapy and compared the results to age-matched normotensive Wistar rats (WR). Our findings show that in SHR the frequency of cells presenting ANP granularity is positively correlated with myocyte size (r=0.746, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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