The Construction of A Sheep Acute Respiratory Distress Syndrome Model Induced by Smoke Inhalation Injury

Autor: Fei YU, Yuan-fei TAN, Guan-nan SHENG, Guan-nan CHEN, Nan-nan WANG, Ting GONG, Bo QU
Rok vydání: 2019
Předmět:
Zdroj: Medical Research. 1:1-11
ISSN: 2664-0341
2664-0333
DOI: 10.6913/mrhk.201912_1(1).0001
Popis: Objective To establish a model of acute respiratory distress syndrome induced by sheep smoke inhalation lung injury. Methods Nine healthy, 12-24 month old, non-pregnant female sheep were randomly selected, the sheep were divided into three groups, through the internal control of smoke generator device components (CO, CO2, O2, particle concentration and smoke temperature, etc.) to adjust the exposure time of the sheep model construction of smoke. The chest CT were examined before and after exposure to smoke at 6h, 12h, 24h and 48h, respectively. From the smoke exposure 12h endotracheal intubation and mechanical ventilation, by adjusting the ventilator parameters of hypoxemia and hypercapnia, statistical analysis of PaO2/FiO2, PEEP and other indicators, according to the ARDS definition of diagnosis in Berlin definition. Results The CT showed mild inflammation of the lungs in first group, oxygen index of 95% confidence interval [331.13, 353.53]; In second groups, oxygenation index 95% confidence interval [220.09, 383.90]; CT showed airway edema, pulmonary inflammatory exudation and lung injury in third group. Oxygenation index 95% confidence interval of [195.16, 244.84], PEEP>5cm. There was significant difference between the two groups (P
Databáze: OpenAIRE
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