MO388: A Critical Evaluation of Anthropological, Biological and Geo-Environmental Factors on Chronic Kidney Disease of unknown Aetiology in Affected Area Against Unaffected Area

Autor: Santhushya Hewapathiranage, Ayesha Nayanamali, Nishantha Nanayakkara
Rok vydání: 2022
Předmět:
Zdroj: Nephrology Dialysis Transplantation. 37
ISSN: 1460-2385
0931-0509
DOI: 10.1093/ndt/gfac070.002
Popis: BACKGROUND AND AIMS Chronic kidney disease of unknown etiology (CKDu) has been a critical health issue among the farming communities of Sri Lanka for decades [1]. However, the distribution of CKDu in Sri Lanka is geographically significant by representing endemicity on its own [2]. This study was conducted to identify the anthropological and geo-environmental characteristics of CKDu, in relation to the biochemical profile between known CKDu endemic and non-endemic communities. METHOD A total of 214 male individuals from Wilgamuwa (endemic) and 102 male individuals from Mathurata (non-endemic) of 30–60 years were recruited. For each participant, blood pressure (BP), random blood sugar (RBS), serum creatinine (μmol/L) and serum cholesterol (mg/dL) were tested using standard methods. Anthropological data including population structure, farming behaviour and poverty statistics were obtained from the respective government officials. Geo climatic data including elevation, monthly average (Avg.) temperature (°C), monthly Avg. rainfall (mm), monthly Avg. humidity (%) and monthly Avg. UV intensity, monthly Avg. Sun hours (hrs.) were obtained for the two study areas. RESULTS Most striking difference between two communities is significantly high serum creatinine (t = 3.5175, P = 0.0005) in male individuals between the age category of 40 to 65 years in CKDu endemic area (M = 109.00, SD = 66.41) in comparison to non-endemic participants in the same age category from non-endemic area for CKDu (M = 85.41, SD = 18.78). The non-endemic area for CKDu, Maturata was colonized since the 16th century due to natural population migrations while the colonization of Wilgamuwa was implemented in a more drastic manner, parallel to the green revolution after the 1960s. Mathurata is located at a high elevation level of 976 m, whereas Wilgamuwa is located at an elevation level of 528 m. In comparison with meteorological variables for the year of 2019, monthly Avg. rainfall (mm) (P = 0.005), monthly Avg. temperature (°C) (P = 0.001), monthly Avg. cloud cover (%) (P = 0.004), monthly Avg. Humidity (%) (P = 0.007), monthly Avg. Sun hours (hrs) (P = 0.001) were highly significant between the two geographical areas. CONCLUSION We report comparably adverse weather conditions, higher exposure to natural and artificial toxic exposure in genetically and behaviourally vulnerable group in the CKDu endemic area in comparison with non-endemic area for CKDu.
Databáze: OpenAIRE
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