Evaluation of thiol disulphide levels in patients with pulmonary embolism
| Autor: | Taha Tahir Bekci, Ozcan Erel, Kamile Yücel, Salim Neselioglu, Ercan Kurtipek, Said Sami Erdem |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty business.industry Biochemistry (medical) Clinical Biochemistry 030208 emergency & critical care medicine medicine.disease Biochemistry Gastroenterology Pulmonary embolism 03 medical and health sciences 0302 clinical medicine chemistry Internal medicine Thiol Medicine In patient business Molecular Biology |
| Zdroj: | Turkish Journal of Biochemistry. 45:559-565 |
| ISSN: | 1303-829X 0250-4685 |
| DOI: | 10.1515/tjb-2019-0259 |
| Popis: | Objectives Maintaining the thiol-disulphide balance is essential for antioxidant defense and apoptosis. The study aimed to evaluate of thiol-disulphide levels in patients with pulmonary embolism (PE). Methods The study included a total of 97 participants: 48 patients and 49 healthy individuals. Serum native thiol (NT), total thiol (TT) and disulphide (DS) levels (µmol/L) were measured using the novel spectrophotometric method. Results We found significantly lower levels of NT (195.44±83.3 μmol/L), DS (20.42±9.20 μmol/L) and TT (236.26±90.66 μmol/L) in patients with PE compared with the healthy controls (304.42±62.13, 24.33±8.09 and 353.07±63.58 μmol/L respectively). Patients with PE had lower serum albumin levels (3.11±1.03 g/dL) and higher ischaemia modified albumin (IMA) levels (0.82±0.16 g/dL) compared with the controls (3.89±0.52 and 0.67±0.15 g/dL, respectively). Serum albumin levels in patients were strongly correlated with plasma IMA (r=−0.737; p Conclusions This study found lower TT, NT and DS levels in patients with PE than in the control group. Our study revealed that thiol-disulphide homeostasis could be altered during PE and further studies are needed to be used as prognostic markers for hospital mortality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|