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Introduction. The questions of the role of the infectious factor in the course of pregnancy, delivery and the newborn state are important due to the need of the determination of the appropriate management to prevent adverse maternal and fetal outcomes. Currently, the issues of extragastric manifestations associated with Helicobacter pylori (Hp) are being investigated, suggesting possible involvement of Hp in pregnancy complications. Study objective is to evaluate the course of early gestosis (emesis gravidarum), depending on the presence of Helicobacter infection in women with chronic gastritis. Material and methods. We examined 120 pregnant women in the gestation period of 8-12 weeks who had early gestational complications: emesis gravidarum, threatened miscarriage, spontaneous miscarriage and stillbirth, which were divided into 2 groups according to the presence of chronic gastritis: group 1 of 58 pregnant women with gastritis and Group 2 of 62 pregnant women without gastritis. Pregnant women with this form of pregnancy complication were additionally examined to perform the study objective of determining the features and frequency of early gestosis (emesis gravidarum). In addition to clinical and laboratory studies performed in accordance with the protocols of the Ministry of Health of Ukraine for the monitoring of pregnant women, the examined patients were diagnosed with a non-invasive Helicobacter pylory method by rapid chromatographic immunoassay for the detection of serum IgG antibodies to Hp. To determine the type of gastritis, the determination of the level of basal secretion of gastrin 17 (G-17) in the serum was performed with the stimulating test with which the presence and severity of atrophy of the mucous membrane of the antral gastric department can be determined. Pregnant women of both groups who had early gestosis (emesis gravidarum) were evaluated for the severity of pregnancy vomiting using a questionnaire method that included an evaluation of clinical and laboratory parameters. The obtained results were processed by methods of mathematical and statistical analysis with the determination of mean values (M ± m), Student’s test and reliability indicator (difference р |
