Alternating Hyperthyroidism and Hypothyroidism in Graves’ Disease: A Case Report and Literature Review
| Autor: | Aqeelah H. Alkhatam, Maryam M. Al-Said, Alya Hassan Alhajjaj |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
Pediatrics medicine.medical_specialty endocrine system diseases biology business.industry Graves' disease Autoantibody General Medicine Disease medicine.disease eye diseases Thyroid-stimulating hormone Blocking antibody medicine biology.protein Thyroid Stimulating Immunoglobulin Antibody Thyroid function business |
| Zdroj: | Case Reports in Clinical Medicine. :361-367 |
| ISSN: | 2325-7083 2325-7075 |
| DOI: | 10.4236/crcm.2020.912050 |
| Popis: | Background: Alternating thyroid function between hypo- and hyperthyroidism is a very rare phenomenon attributed to the switch between the types of thyroid stimulating hormone receptor autoantibodies; thyroid stimulating antibody and thyroid stimulating hormone blocking antibody. Case Presentation: We report an 18 years old male who presented with hyperthyroidism attributed to Graves’ disease. He was treated with antithyroid medication. During follow up, his thyroid function was switching between hyper- and hypothyroidism which was difficult to treat with antithyroid medication. His laboratory investigations revealed high thyroid stimulating immunoglobulin and TSH binding inhibitory immunoglobulin. Due to the difficultly of managing him with antithyroid medication, he was offered a definitive management for his Graves’ disease. Conclusion: This case demonstrates a rare challenging presentation of Graves’ disease. Patients presenting with fluctuation in thyroid function between hyper-and hypothyroidism need a definitive management for Graves’ disease. |
| Databáze: | OpenAIRE |
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