Differential Effects of the Antioxidants N-Acetylcysteine and Pyrrolidine Dithiocarbamate on Mesenchymal Stem Cell Chondrogenesis
| Autor: | John D. Kisiday, Suwimol Tangtrongsup |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Reactive oxygen species Mesenchymal stem cell 02 engineering and technology 021001 nanoscience & nanotechnology Chondrogenesis medicine.disease_cause General Biochemistry Genetics and Molecular Biology Cell biology Acetylcysteine Extracellular matrix 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Pyrrolidine dithiocarbamate Modeling and Simulation medicine 0210 nano-technology Intracellular Oxidative stress medicine.drug |
| Zdroj: | Cellular and Molecular Bioengineering. 12:153-163 |
| ISSN: | 1865-5033 1865-5025 |
| DOI: | 10.1007/s12195-019-00566-3 |
| Popis: | Introduction Mesenchymal stem cell (MSC) chondrogenesis is associated with increases in intracellular reactive oxygen species (ROS), which may result in oxidative stress that is detrimental to cartilage regeneration. This study evaluated the ability of the antioxidants N-acetylcysteine (NAC) or pyrrolidine dithiocarbamate (PDTC) to reduce intracellular ROS, and their effect on MSC chondrogenesis and maturation of cartilage-like extracellular matrix. |
| Databáze: | OpenAIRE |
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