Instant coffee extract with high chlorogenic acids content inhibits hepatic G-6-Pasein vitro, but does not reduce the glycaemia

Autor:	Clairce Luzia Salgueiro-Pagadigorria, Roberto Barbosa Bazotte, Bruna Kempfer Bassoli, Glaucia Regina Borba-Murad, Priscila Cassolla, Helenir Medri de Souza, Jorgete Constantin
Rok vydání:	2015
Předmět:	Liver perfusion Glycogenolysis biology Clinical Biochemistry Cell Biology General Medicine Glucose output Biochemistry In vitro chemistry.chemical_compound Chlorogenic acid chemistry biology.protein G 6 pase Glucose 6-phosphatase Instant
Zdroj:	Cell Biochemistry and Function. 33:183-187
ISSN:	0263-6484
DOI:	10.1002/cbf.3099
Popis:	Coffee is the main source of chlorogenic acid in the human diet, and it contains several chlorogenic acid isomers, of which the 5-caffeoylquinic acid (5-CQA) is the predominant isomer. Because there are no available data about the action of chlorogenic acids from instant coffee on hepatic glucose-6-phosphatase (G-6-Pase) activity and blood glucose levels, these effects were investigated in rats. The changes on G-6-Pase activity and liver glucose output induced by 5-CQA were also investigated. Instant coffee extract with high chlorogenic acids content (37.8%) inhibited (p 0.05). Similarly, 5-CQA (1 mM) reduced (p 0.05) on glucose output arising from glycogenolysis in liver perfusion. It was concluded that instant coffee extract with high content of chlorogenic acids inhibited hepatic G-6-Pase in vitro, but failed to reduce the glycaemia probably because the coffee chlorogenic acids did not reach enough levels within the hepatocytes to inhibit the G-6-Pase and reduce the liver glucose output. Copyright © 2015 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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