Myocardial oxygen consumption and perfusion before and after cardiac resynchronization therapy: experimental observations and clinical implications*1
| Autor: | W. Burchert, D. Baller, J. Holzinger, P. Wielepp, B. Lamp, Dieter Horstkotte, Juergen Vogt, A. Kammeier, O. Lindner |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Ejection fraction business.industry medicine.medical_treatment Cardiac resynchronization therapy medicine.disease QRS complex Rate pressure product Myocardial oxygen consumption Heart failure Internal medicine medicine Cardiology Cardiology and Cardiovascular Medicine business Perfusion Energy (signal processing) |
| Zdroj: | European Heart Journal Supplements. 6:D91-D97 |
| ISSN: | 1520-765X |
| DOI: | 10.1016/j.ehjsup.2004.05.001 |
| Popis: | Aims Experimental studies indicated unfavourable effects on myocardial energetics and efficiency under asynchronous ventricular stimulation, also shown for left bundle branch block (LBBB) pattern. We noninvasively analyzed the effects on myocardial oxygen consumption (MVO2), perfusion (MBF) and pressure work efficiency by positron emission tomography (PET) before and after resynchronization therapy (CRT) in 31 patients with dilated cardiomyopathy (DCM) and LBBB. Methods 31 patients (19 males, 12 females) with DCM were studied at baseline and 3–4 months follow-up. Baseline characteristics: age 61±7 years; NYHA class 3.0±0.4, ejection fraction 22.1±7.1%, QRS duration 187±19 ms. MVO2 and MBF were measured from 11C-acetate kinetics with PET by a one-compartment model. MVO2 and MBF were normalized to rate pressure product (RPP) to account for different pressure loads and predicted energy demands. Results Global MVO2 assessed from 11C-acetate clearance did not change significantly between baseline and follow-up (0.080±0.015/min vs. 0.082±0.020/min). RPP-normalized MVO2 significantly decreased after CRT (0.072±0.018/min) vs. baseline (0.081±0.017/min; \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(P{ |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|