Assessment of Interleukin (8) in Type 2 Diabetes Mellitus
| Autor: | Mahmoud Mohammed Mohammed Metwally, Mekky Abd El Monem Aly, Ihab Nehad Farhan Mohammed, Ilham Aly Motawa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry Insulin medicine.medical_treatment Type 2 Diabetes Mellitus Interleukin 030209 endocrinology & metabolism Inflammation Type 2 diabetes medicine.disease Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus medicine 030211 gastroenterology & hepatology Interleukin 8 medicine.symptom business |
| Zdroj: | The Egyptian Journal of Hospital Medicine. 72:4403-4406 |
| ISSN: | 2090-7125 |
| DOI: | 10.21608/ejhm.2018.9298 |
| Popis: | Background: Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long- term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Type 2 diabetes (T2D) is characterized by a condition of systemic low-grade inflammation. IL-8 is an important member of the chemokine family of proinflammatory chemotactic cytokines. IL-8 was initially characterized as a potent chemoattractant of neutrophils and was later shown to also activate neutrophils. IL-8 is also known to be a potent promoter of angiogenesis. Objective: It was the Assessment of Interleukin (8) in Type 2 Diabetes Mellitus. Patients and Methods: Serum IL 8 level in Type 2 Diabetes Mellitus. 30 patients compared to 30 normal individuals were included in this study. Results: There was a highly statistical significant difference between all patients and control groups as regard serum IL 8 level (mean of serum IL 8 in patients and control groups were 69.9 ± 20.5 and 5.4 ± 3.3 respectively, p= < 0.001). Conclusion: Type 2 diabetes mellitus patients showed marked elevation of circulating IL-8 levels which identify subjects with worse inflammatory state and metabolic control and therefore it may be used as a marker for the rate of development of diabeteic complications. |
| Databáze: | OpenAIRE |
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