Effect of Ocimum basilicum, Ocimum selloi, and Rosmarinic Acid on Cerebral Vascular Damage in a Chronic Hypertension Model
| Autor: | Macrina Fuentes-Mata, Margarita Avilés-Flores, Enrique Jiménez-Ferrer, Elian Alegría-Herrera, Mayra Alejandra Santillán-Urquiza, Alejandro Zamilpa, Maribel Herrera-Ruiz, Rubén Román-Ramos, María Isabel Aguilar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology Elevated plus maze biology business.industry Rosmarinic acid Pharmaceutical Science General Medicine Ocimum biology.organism_classification Angiotensin II Proinflammatory cytokine 03 medical and health sciences chemistry.chemical_compound Interleukin 10 030104 developmental biology 0302 clinical medicine chemistry 030220 oncology & carcinogenesis biology.protein Medicine Interleukin 6 business Interleukin 4 |
| Zdroj: | Biological and Pharmaceutical Bulletin. 42:201-211 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.b18-00574 |
| Popis: | The main objective of treatment against hypertension is not only to reduce blood pressure levels, but also to reduce vascular risk in general. In the present work, administering angiotensin II (AGII; 0.2 µg/kg intraperitoneally (i.p.) for 12 weeks) activates the hypothalamic-pituitary-adrenal (HPA) axis, which caused an increase in corticosterone levels, as well as in proinflammatory cytokines (interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α)) and macrophage chemotactic protein 1 (MCP-1), and decreased anti-inflammatory cytokines (interleukin 10 (IL-10) and interleukin 4 (IL-4)). On observing the behavior in the different models, an anxiogenic effect (elevated plus maze (EPM)) and cognitive impairment (water Morris maze (WMM)) was observed in animals with AGII. By administering organic extracts from Ocimum basilicum (Oba-EtOAc) and Ocimum selloi (Ose-EtOAc), and some doses of rosmarinic acid (RA) (6 weeks per os (p.o.)), the damage caused by AGII was stopped by re-establishing corticosterone serum levels and by decreasing the proinflammatory cytokines and MCP-1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|