Thirteen novel canine dog leukocyte antigen-88 alleles identified by sequence-based typing
| Autor: | Beverly Torok-Storb, R Storb, Scott S. Graves, Michael A. Harkey, Gopalakrishnan M. Venkataraman, Lorna J. Kennedy, Marie-Térèse Little |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genetics biology Dog leukocyte antigen Immunology MHC Class I Gene Human leukocyte antigen Major histocompatibility complex Histocompatibility Transplantation 03 medical and health sciences 030104 developmental biology 0302 clinical medicine biology.protein Immunology and Allergy Gene polymorphism Progenitor cell 030215 immunology |
| Zdroj: | HLA. 90:165-170 |
| ISSN: | 2059-2302 |
| DOI: | 10.1111/tan.13077 |
| Popis: | Major histocompatibility complex (MHC) genes in mammals include highly polymorphic class I and class II genes that are critical for donor-recipient matching for transplantation. Dogs have served as an effective, directly translatable model for stem/progenitor cell transplantation. Previous analyses of MHC class I genes in dogs point to a single highly polymorphic gene, dog leukocyte antigen (DLA)-88, as an important factor in the success or failure of hematopoietic stem cell transplants. Fifty-nine DLA-88 alleles have been identified and reported so far. Here, we extend this list by presenting 13 novel DLA-88 alleles found in domestic dogs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |