Melipatulinones A–C, Three Lignan–Phloroglucinol Hybrids from Melicope patulinervia
| Autor: | Xin-lin Chen, Jian-Guang Luo, Van-Tuan Vu, Ling-Yi Kong |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Lignan
chemistry.chemical_classification Circular dichroism biology 010405 organic chemistry Stereochemistry Organic Chemistry Phloroglucinol Stereoisomerism 010402 general chemistry Ring (chemistry) biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Melicope chemistry Physical and Theoretical Chemistry Enantiomer Tricyclic |
| Zdroj: | Organic Letters. 22:1380-1384 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | (±)-Melipatulinones A–C (1–3), three unique enantiomeric pairs of lignan–phloroglucinol hybrids along with the biogenetically related compound melipatulignan A (4), were isolated from the leaves of Melicope patulinervia. Melipatulinones A (1) and B (2) share a novel spiro[hydrobenzofuran-2,3′-furan] 5/5/6 tricyclic ring system, while melipatulinone C (3) features an unprecedented spiro[cyclopenta[b]hydrofuran-2,3′-furan] 5/5/5 tricyclic framework. Their structures were determined by spectroscopic methods, electronic circular dichroism (ECD) calculations, and X-ray diffraction. Compounds 1–3 exhibited a pancreatic lipase inhibitory effect. |
| Databáze: | OpenAIRE |
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