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The purpose of this study was to estimate effect of drugs on red blood cell (RBC) microrheological properties. Despite of simplification, mature erythrocytes retain a number of molecular components of signaling pathways and so drugs can affect on cellular function including their flow deformation and O2-transport capacity. It was found that hormones: epinephrine (10− 6 M) and insulin (70 pM) changed red blood cell deformability (RBCD) and aggregation (RBCA). It was shown that RBCD and RDCA were variable under adenylyl cyclase (AC) activation by forskolin or dibutyryl cAMP (dB-cAMP; 10− 4M), therefore one of the cellular molecular target for RBC microrheological change can be AC. It was found that all four phosphodiesterase (PDE) inhibitors: IBMX, vinpocetine, rolipram, pentoxifylline decreased RBCA significantly (by 30-50%, p |
