Effects of tablet core dimensional instability on the generation of internal stresses within film coats part I: Influence of temperature changes during the film coating process

Autor:	J. E. Hogan, E. Okutgen, M. E. Aulton
Rok vydání:	1991
Předmět:	Pharmacology Materials science Starch Organic Chemistry Pharmaceutical Science Core (manufacturing) engineering.material Compression (physics) Maize starch Viscoelasticity Film coating chemistry.chemical_compound Coating chemistry Drug Discovery engineering Relaxation (physics) Composite material
Zdroj:	Drug Development and Industrial Pharmacy. 17:1177-1189
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049109043852
Popis:	Commercial-sized (10mm diameter and 3.1mm thick) flat-faced tablets, formed from three direct compression bases (Avicel PH101, Emcompress and Starch 1500) and from maize starch, were stored at ambient conditions for 1, 24, 48 and 72 hours following their compression, then exposed to temperatures of 30 and 40°C for two hours, and afterwards allowed to re-equilibrate to room temperature for another two hours. The aim of this was to simulate temperature variations experienced during a typical film coating process. During this time, dimensional changes of the tablets were measured by means of a free-armature transducer rig. The dimensional changes occurring during the preliminary ambient storage due to viscoelastic strain relaxation were found to be significant, but were much smaller In magnitude compared to those occurring during the subsequent heating/cooling cycle which is part of the tablet coating process. Tablets of Avicel, maize starch and Starch 1500 decreased in size during heating and expand...
Databáze:	OpenAIRE
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