Correlates of infection withHelicobacter pyloripositive and negative cytotoxin-associated gene A phenotypes among Arab and Jewish residents of Jerusalem
| Autor: | D. Cohen, Kh. Muhsen, Hisham Nassar, Jeremy D. Kark, W. Abu Ahmed, Gany Beer-Davidson, R. Sinnereich |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
education.field_of_study
Epidemiology Population Virulence Biology Helicobacter pylori bacterial infections and mycoses biology.organism_classification Immunoglobulin G Serology 03 medical and health sciences 0302 clinical medicine Infectious Diseases Antigen 030220 oncology & carcinogenesis Immunology biology.protein CagA 030211 gastroenterology & hepatology Antibody education |
| Zdroj: | Epidemiology and Infection. 147 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268819001456 |
| Popis: | We examined the prevalence and correlates ofHelicobacter pylori(H. pylori) infection according to cytotoxin-associated gene A (CagA) phenotype, a main virulence antigen, among the ethnically diverse population groups of Jerusalem. A cross-sectional study was undertaken in Arab (N= 959) and Jewish (N= 692) adults, randomly selected from Israel's national population registry in age-sex and population strata. Sera were tested forH. pyloriimmunoglobulin G (IgG) antibodies. Positive samples were tested for virulence IgG antibodies to recombinant CagA protein, by enzyme-linked immunosorbent assay. Multinomial regression models were fitted to examine associations of sociodemographic factors withH. pyloriphenotypes.H. pyloriIgG antibody sero-prevalence was 83.3% (95% confidence interval (CI) 80.0%–85.5%) and 61.4% (95% CI 57.7%–65.0%) among Arabs and Jews, respectively. AmongH. pyloripositives, the respective CagA IgG antibody sero-positivity was 42.3% (95% CI 38.9%–45.8%) and 32.5% (95% CI 28.2%–37.1%). Among Jews, being born in the Former Soviet Union, the Middle East and North Africa,vs.Israel and the Americas, was positively associated with CagA sero-positivity. In both populations, sibship size was positively associated with both CagA positive and negative phenotypes; and education was inversely associated. In conclusion, CagA positive and negative infection had similar correlates, suggesting shared sources of these twoH. pyloriphenotypes. |
| Databáze: | OpenAIRE |
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